David Tepper – balanced, clear thinker
“Selenium and zinc levels might be low causing an increase in rT3.” – from http://forum.bulletproofexec.com/index.php?/topic/4603-weird-testosterone-results/?view=findpost&p=35346
Respectable Ron Swanson (of Hope Mills, NC – might have doctor recommendation!) typed: “
Hackergirl is right about an iodine loading test, but increased TSH is an indicator of the health of your pituitary gland more than your thyroid gland. The free test being low is what worries me and it might be the reason why your test is high. All your test is bounded up and your body is trying to increase test to make up for it.
I would suggest supplementing DIM, Fish Oil (Life Extension), and a good Zinc (L-Opti Zinc By: Jarrow). This should help increase your free test while lowering your total test.”
My CRP was only 0.5 a day after running some sprints. Since CRP is “secreted from the liver in response to IL-6″ (Wilund, 2007), I suppose this means I am in good shape with IL-6. Jack Kruse mentions IL-6 and CRP quite a few times in his book, “Epi-Paleo RX” as associated with leptin resistance as I recall.
Kruse typed on http://www.jackkruse.com/hormone-cpc-1-dhea/ to me an explanation for why he is “a big believer in superphysiologic doses today for many people using DHEA when we live in an tsunami of pulsed EMF”.
“Attention control is associated with higher HRV” from http://sharpbrains.com/blog/2007/02/11/heart-rate-variability-as-an-index-of-regulated-emotional-responding/*** I plan to use my EmWave2 before and after the neurofeedback session tomorrow.
2013 refers to mid-April and 2012 refers to Mid-July that year.
This research and notes largely inspired by Ben Greenfield’s work, as perhaps first documented at <http://www.bengreenfieldfitness.com/2013/05/what-happens-to-your-body-after-you-do-a-hard-workout-triathlon-or-marathon/>.
My free testosterone has been lower than expected given my total testosterone levels every single time I have tested it. It was a scary 5.5 (8.7 – 25.1) a couple weeks ago, a huge drop from the 9.1 only a month prior when I performed tests for which other results are posted below. The huge drop might have been a product of sleep quality reduction from using Adaptogen N (DHEA affected sleep? Unusual response to Suma or something else in the product?). I am suspicious though because I have other free testosterone results from last year when I was probably using the product.
Setting the mysterious huge drop and the associated effect on my mood (irritability, less verve), the basic idea is that a previously unrecognized thyroid problem may be causing my SHBG to stay high. Free triiodothyronine (T3?) has been associated with higher SHBG (http://www.ncbi.nlm.nih.gov/pubmed/14558918). My April, 2013 TSH inexplicably jumped to 2.0 from 0.85 in 2012, a fluctuation that could be evidence of an autoimmune thyroid problem. I therefore had a complete thyroid panel (with cortisol) performed Friday and hope to get the result tomorrow.
Blood Test Results and research from stopthethyroidmadnesss.com
My TIBC was 270 (250-450) and I want to get this to at least 300.
My iron was 102 (40-155), up nicely from 81 in 2012. Might reflect iron provided by dessicated liver (Universal Nutrition) – watch out for constipation, combat with additional magnesium glycinate.
My ferritin was 102 (30-400). I’m not sure if this could reflect inflammation. Some say elevated ferritin relative to TIBC (so normal ferritin vs. my low-normal TIBC) can indicate inflammation.
I meet no criteria for various kinds of anemia in the table at http://labtestsonline.org/understanding/analytes/tibc/tab/test, but I am closest to “chronic illness”. I have only tested iron previously amongst the tests in this table but its increase by 25% could mean I am defeating the illness.
“TIBC (Total iron binding capacity) test: measures whether a protein called transferrin, produced by the liver, has the ability to carry iron in the blood. Used to determine anemia or low body iron. It your result is high, and in the absence of chronic disease, you may be anemic. With healthy amounts of iron, this test will be low in the range—about 1/4th above the bottom number.”
** My oral temperature has been below 98.6 every time I have checked it while not sick over the last 10 years or so. I just tested at 98.1 (11 AM after a significant amount of bulletproof coffee), which is better than what I recall it previously being (97.5-97.9).
A physician said in about 2006 that my hematocrit was a little low for a young man. I am up to 42.7 now from 40.5 (37.5-51) in 2012 (optimal is 42-48 according to Dr. Kaslow). Hemoglobin is up to 13.7 from 12.8 (optimal is 14.0 – 15.0 according to Dr. Kaslow). MCV up to 86 from 84 (optimal is 87-92 according to Dr. Kaslow). RBCs virtually unchanged – 4.99 (4.14 – 5.8) in 2013 – I’m in the optimal range (4.7 – 5.25) according to http://www.drkaslow.com/html/blood_cell_counts.html [Dr. Jeremy E Kaslow].
“…being hypothyroid can result in a lowered production of stomach acid which in turn leads to the malabsorption of iron, whether revealed with low ferritin, or with inadequate levels of serum or saturation. It can also lower your body temperature (common for those on T4-only thyroxine, as well) which causes you to make less red blood cells.”
“This study reveals that an iron-containing protein is present in high amounts in the adrenal cortex and is involved in the synthesis of corticosterone. So by having low iron, you can potentially lower your cortisol levels.”
“Iron, in addition to iodine, selenium and zinc, are essential for normal thyroid hormone metabolism.”
I worried that my platelets were getting too high (342 from 264 in 2012, optimal is 230-400 according to Dr. Kaslow) and blood donation would be wise despite some components of RBC counts being below normal. I remain in the optimal range so I will hold off on donating blood.
RDW is up to 14.6 from 14.3, Doctor Kaslow has the optimum stated as only “13″ and various kinds of anemia including B12 and Folic acid can cause increases. I am going to try supplementing with more B12 and Folic Acid to reduce the RDW. I bought a soon-to-expire powerful Vitamin B complex from Vitamin Shoppe and will strongly consider resuming the Ageforce Vitamin B patches since they have what appear to be the best forms of Vitamin B (such as uncommon methylfolate instead of usual folic acid) and my B12/Folate levels were higher when I used those patches in 2012 (793 vs. 651, 17.4 vs. 11.1). I think I was using a multivitamin as well last year. I’d like to get my B12 above 1000 per the recommendation of Dr. Jack Kruse in “Epi-paleo RX”, which I have seen supported elsewhere.
“Plasma SHBG levels are correlated positively whereas CBG levels are correlated negatively with free thyroid hormone concentrations in men as well as women.“
Eur J Endocrinol. 1995 May;132(5):594-8.
Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans.
Dumoulin SC, Perret BP, Bennet AP, Caron PJ.
*** found at http://www.mindandmuscle.net/forum/35-hrt-trt/36043-shbg-free-testosterone-2.html, posted by Dr. Adel Moussa (Physicus007 / ProfDrAndro)
Testosterone binds to albumin or SHBG.
Recent blood tests show that I lowered my testosterone by about 100 points and my free testosterone fell below the normal range (about 40% lower to 5.5 pg/mL) after doubling my zinc to 60 mgs/day (copper to 600 mcg) and using a supplement with DHEA, melatonin and other compounds at night (Adaptogen-N). My suspicion is that Adaptogen-N affected my sleep poorly, although I enjoyed waking up earlier in the morning. I eventually found myself feeling more tired, hence the retest a month after the first.
A Life Extension Foundation doctor named Brooke recommended I do the following, and I will:
- Move the DHEA to the morning @ 25 mgs/d, increase pregnenolone to 30 mgs/day (she preferred oral supplementation but I am going through my transdermal cream first)
- Use their Super Miraforte at 2 in the AM and 2 in the PM
- Continue with zinc (forgot to tell her my Optizinc includes a little copper)
- Use L-carnitine at 2-4 grams per day because of a possibly thyroid issue (see next paragraph)
- Do a full thyroid panel (see next paragraph)
- Add calming herbs – my wife mentioned our possession of a relaxation-targeted tea
- Retest in 3-6 months
Thyroid and SHBG
The one recent TSH test I have is from the middle of last year and shows 0.85 (0.45-5.00). While clearly in the clinically normal range, Life Extension suggests 1-2 uIU/mL, and my elevated anxiety as of late suggest a possible thyroid problem (hyperthyroid). Also, my recent SHBG (sex hormone binding globulin) result was very high [86.6 (16.5-55.9), and she said thyroid hormone T4 increases SHBG. My free T3 (triiodothyronine) result from mid-2012 showed only 3.3 (2.0-4.4) and I do not know if T3 and T4 tend to covary.
Recent psychology and observations
More irritable and anxious than usual. Temper flares rapidly. Movement helps me calm down. Still very motivated to exercise. ADD symptoms worse.
Life Extension Male Hormone Restoration
“Fish oil: A study examined how the essential fatty acids EPA and DHA affected SHBG levels in men 43 to 88 years of age (Nagata et al 2000). After controlling for other variables, the researchers concluded that both EPA and DHA decreased levels of SHBG in middle-aged and elderly men.”
- Article in Table 2 reports age positively associated with SHBG (no surprise) and alcohol intake inversely associated (quite surprising especially estrogen was positively associated with alcohol intake).
- Life Extension and others have conveniently left out the above finding as well as that omega-3 consumption was inversely associated with total testosterone, and by a very similar statistical finding, dietary cholesterol was inversely associated with total testosterone and SHBG.