Monthly Archives: May 2013

SHBG notes


“Plasma SHBG levels are correlated positively whereas CBG levels are correlated negatively with free thyroid hormone concentrations in men as well as women.

Eur J Endocrinol. 1995 May;132(5):594-8.
Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans.
Dumoulin SC, Perret BP, Bennet AP, Caron PJ.
*** found at, posted by Dr. Adel Moussa (Physicus007 / ProfDrAndro)


Testosterone binds to albumin or SHBG.


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Blood test results – lower T, low free T, high SHBG + Doc recommendations

Recent blood tests show that I lowered my testosterone by about 100 points and my free testosterone fell below the normal range (about 40% lower to 5.5 pg/mL) after doubling my zinc to 60 mgs/day (copper to 600 mcg) and using a supplement with DHEA, melatonin and other compounds at night (Adaptogen-N). My suspicion is that Adaptogen-N affected my sleep poorly, although I enjoyed waking up earlier in the morning. I eventually found myself feeling more tired, hence the retest a month after the first.

A Life Extension Foundation doctor named Brooke recommended I do the following, and I will:

  1. Move the DHEA to the morning @ 25 mgs/d, increase pregnenolone to 30 mgs/day (she preferred oral supplementation but I am going through my transdermal cream first)
  2. Use their Super Miraforte at 2 in the AM and 2 in the PM
  3. Continue with zinc (forgot to tell her my Optizinc includes a little copper)
  4. Use L-carnitine at 2-4 grams per day because of a possibly thyroid issue (see next paragraph)
  5. Do a full thyroid panel (see next paragraph)
  6. Add calming herbs – my wife mentioned our possession of a relaxation-targeted tea
  7. Retest in 3-6 months

Thyroid and SHBG

The one recent TSH test I have is from the middle of last year and shows 0.85 (0.45-5.00). While clearly in the clinically normal range, Life Extension suggests 1-2 uIU/mL, and my elevated anxiety as of late suggest a possible thyroid problem (hyperthyroid). Also, my recent SHBG (sex hormone binding globulin) result was very high [86.6 (16.5-55.9), and she said thyroid hormone T4 increases SHBG. My free T3 (triiodothyronine) result from mid-2012 showed only 3.3 (2.0-4.4) and I do not know if T3 and T4 tend to covary.

Recent psychology and observations

More irritable and anxious than usual. Temper flares rapidly. Movement helps me calm down. Still very motivated to exercise. ADD symptoms worse.

Life Extension Male Hormone Restoration


“Fish oil: A study examined how the essential fatty acids EPA and DHA affected SHBG levels in men 43 to 88 years of age (Nagata et al 2000). After controlling for other variables, the researchers concluded that both EPA and DHA decreased levels of SHBG in middle-aged and elderly men.”


  • Article in Table 2 reports age positively associated with SHBG (no surprise) and alcohol intake inversely associated (quite surprising especially estrogen was positively associated with alcohol intake).
  • Life Extension and others have conveniently left out the above finding as well as that omega-3 consumption was inversely associated with total testosterone, and by a very similar statistical finding, dietary cholesterol was inversely associated with total testosterone and SHBG.


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MCT oil –

“Effect of a fat spread enriched with medium-chain triacylglycerols…on cardiometabolic risk factors in overweight patients with diabetes” (Siener, Nutrition and Metabolism. 2011)

Article’s table 2 shows waist circumference fell 2 cm in those consuming >7g/day of MCT oil versus those consuming <=7g/day who lost nothing. Body weight did not change so I suppose the high-MCT users lost fat and gained muscle. Uric acid increased about 5% in high-MCT group. Suppversity and have reported on health problems possibly associated with increase of lineoleic acid in our diet and MCT oil consumption in both groups was associated with at least 37% reduction in LA/(EPA+EPA+DHA) consumed.  Fasting triglycerides curiously increased in both MCT groups. [all differences here were statistically significant].

Article also summarizes: Omega-3 fatty acids (n-3-PUFA) are anti-inflammatory, anti-thrombotic, and anti-arrhythmic, and EPA/DHA in particular lower triglycerides.

On MCT and ketone production:

“I would be lead to believe that the increase in ketones in the morning is due to low(er) insulin levels and high(er) cortisol levels increasing the break down of fat stores…. as we know, the incomplete breakdown of FFAs in the liver is what creates a ketone body.”

“The reason [Bulletproof Intermittent Fasting] is “ketogenic” is because of the medium chain triglycerides from MCT Oil and short chain fats of butter.”

“IFing causes an increase in GH and Test. so you will mobilize fat easily during the fast, especially around the hard to lose areas such as the belly. Ketosis will aid in fat burning, too, but not necessarily because of surges of GH/Test., but because you are mobilizing massive amounts of fatty acids and the low insulin promotes your body to utilize fat rather than put everything you eat into storage at the liver, muscle, or fat cell.”

Commenter BigPapaCharka in post 11 of Bulletproof Forum (Dave Asprey’s) blog at

I would be lead to believe that the increase in ketones in the morning is due to low(er) insulin levels and high(er) cortisol levels increasing the break down of fat stores…. as we know, the incomplete breakdown of FFAs in the liver is what creates a ketone body.

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